Archives
Looking into the Future of Foods and Health
J Bruce German
Department of Food Science and Technology, University of California, Davis CA, United States of America
Abstract
The health of the population is compromised by poor dietary choices. Resolving this situation will require a substantial investment at many levels of science, agriculture and food industrialisation. If such investments are undertaken they will provide the opportunity to change the food marketplace from a product centric, to a consumer centric, strategy competing to deliver health benefits to individuals.
Keywords
food, health, assessment, personalising, metabolomics, food reformulation
Article Text
The food industry has a unifying goal to deliver to the marketplace safe, convenient, affordable and delicious food products that provide consumers the means to assemble the diets that maintain and improve their health. Scientific research has built considerable basic knowledge that has been instrumental in achieving this goal. Examples of prior success abound, from the scientific discoveries of the essential nutrients to the engineering of unit operations that ensure the reliable and controlled lethality of potential food borne pathogens in food processing lines. This knowledge ensured that the population consumed foods that provided all of the essential nutrients within a normal diet and was protected from the broad range of food borne microbial pathogens in the environment. The overall success of the industrial translation of this science is illustrated by the observation that most of the Western population is now unaware of, that is, has never seen the phenotypes of diseases caused by classic deficiency diseases, iodine – goitre, vitamin C – scurvy, vitamin A – blindness, and rarely experiences food borne illness from the consumption of industrialised foods.
..continued..
References
Alberti G (2001) Noncommunicable diseases: tomorrow's pandemics. Bulletin of the World Health Organsisation 79: 907.
Aung K, Burnett J, Smith SM and Dyer CB (2006) Vitamin D deficiency associated with self-neglect in the elderly. Journal of Elderly Abuse and Neglect 18: 63–78.
Backstrand JR (2002) The history and future of food fortification in the United States: a public health perspective. Nutrition Reviews 60: 15–26.
Bateson P, Barker D, Clutton-Brock T, Deb D, D'Udine B, Foley RA, Gluckman P, Godfrey K, Kirkwood T, Lahr MM, McNamara J, Metcalfe NB, Monaghan P, Spencer HG and Sultan SE (2004) Developmental plasticity and human health. Nature 430: 419–421.
Bertéus Forslund H, Torgerson JS, Sjöström L and Lindroos AK (2005) Snacking frequency in relation to energy intake and food choices in obese men and women compared to a reference population. International Journal of Obesity (London) 29: 711–719.
Bruin S and Jongen THRG (2003) Food process engineering: the last 25 years and the challenges ahead, Critical Reviews of Food Science and Food Safety 2: 42–81.
Cannell JJ, Hollis BW, Zasloff M and Heaney RP (2008) Diagnosis and treatment of vitamin D deficiency. Expert Opinions in Pharmacotherapy 9: 107–118.
Catchpole GS, Beckmann M, Enot DP, Mondhe M, Zywicki B, Taylor J, Hardy N, Smith A, King RD, Kell DB, Fiehn O and Draper J (2005) Hierarchical metabolomics demonstrates substantial compositional similarity between genetically modified and conventional potato crops, Proceedings of the National Academy of Sciences (USA) 102: 14458–14462.
Chakravarty I and Sinha RK (2002)Prevalence of micronutrient deficiency based on results obtained from the national pilot program on control of micronutrient malnutrition. Nutrition Review 60: S53–8.
Clydesdale FM (1997) A proposal for the establishment of scientific criteria for health claims for functional foods. Nutrition Review 55: 413–422.
Clydesdale F (2004) IFT Expert Panel Report on Functional Foods: Opportunities and challenges. Food Technology 58: 35–40.
Colhoun HM (2007) Lipid goals in metabolic syndrome and diabetes. Current Atherosclerosis Reports 9: 286–295.
Collins FS, Green ED, Guttmacher AE, Guyer MS and US National Human Genome Research Institute (2003) A vision for the future of genomics research. Nature 422: 835–847.
Daar AS, Singer PA, Persad DL et al (2007) Grand challenges in chronic non-communicable disease. Nature 450: 494–495.
de Campo L, Yaghmur A, Sagalowicz L, Leser ME, Watzke H and Glatter O (2004) Reversible phase transitions in emulsified nanostructured lipid systems. Langmuir 20: 5254–5261.
Delmer DP (2005) Agriculture in the developing world: Connecting innovations in plant research to downstream applications, Proceedings of the National Academy of Sciences (USA) 102: 15739–15746.
European Plant Science Organization (2005) European plant science: a field of opportunities, Journal of Experimental Botany 56: 1699–1709.
Fay LB and German JB (2008) Personalising foods: Is genotype necessary? Current Opinions in Biotechnology Apr 3 [Epub ahead of print].
Flickinger BD (2007) Utilizing biotechnology in producing fats and oils with various nutritional properties. Journal AOAC International 90: 1465–1469.
German JB, Schanbacher FL, Lönnerdal B, Medrano J, McGuire M, McManaman JL, Rocke DM, Smith TP, Neville MC, Donnelly P, Lange MC and Ward RE (2006) International milk genomics consortium. Trends in Food Science Technology 17: 656–661.
German JB, Hammock BD and Watkins SM (2005a) Metabolomics: Building on a century of biochemistry to guide human health. Metabolomics 1: 3–8.
German JB, Yeretzian C and Watzke HJ (2005b) Personalising foods for health and preference. Food Technology 58: 26–31.
Gibney MJ, Walsh M, Brennan L, Roche HM, German B and van Ommen B (2005) Metabolomics in human nutrition: opportunities and challenges. American Journal of Clinical Nutrition 82: 497–503.
Gould GW (2000) Preservation: Past, present and future, British Medical Bulletin 56: 84–96.
Grigorov MG (2005) Global properties of biological networks, Drug Discovery Today 10: 365–372.
Grundy SM (2002) National Cholesterol Education Program (NCEP) – The National Cholesterol Guidelines in 2001, Adult Treatment Panel (ATP) III. Approach to lipoprotein management in 2001 National Cholesterol Guidelines. American Journal of Cardiology 90: 11i–921i.
Guevera VR (2004) Use of nonlinear programming to optimize performance response to energy density in broiler feed formulation. Poultry Science 83: 147–151.
Haeckel R, Raber R and Wosniok W (2006) Comparability of indices for insulin resistance and insulin secretion determined during oral glucose tolerance tests. Clinical Chemistry and Laboratory Medicine 44: 817–23.
Hobbs SH (2005) Attitudes, practices, and beliefs of individuals consuming a raw foods diet. Explore (NY) 1: 272–277.
Holden JM, Lemar LE and Exler J (2008) Vitamin D in foods: development of the US Department of Agriculture database. American Journal of Clinical Nutrition 87: 1092S–1096S.
Krauss RM (2001) Dietary and genetic effects on low‑density lipoprotein heterogeneity, Annual Reviews of Nutrition 21: 283–295.
Lacroix M, Bos C, Léonil J, Airinei G, Luengo C, Daré S, Benamouzig R, Fouillet H, Fauquant J, Tomé D and Gaudichon C. Compared with casein or total milk protein, digestion of milk soluble proteins is too rapid to sustain the anabolic postprandial amino acid requirement. American Journal of Clinical Nutrition 84: 1070–1079.
Lai CQ, Tai ES, Tan CE, Cutter J, Chew SK, Zhu YP, Adiconis X and Ordovas JM (2003) The apolipoprotein A5 locus is a strong determinant of plasma triglyceride concentrations across ethnic groups in Singapore, Journal of Lipid Research 44: 2365–2373.
Lange MC, Lemay DA and German JB (2007) Multi-ontology framework to guide agriculture and food toward diet and health, Journal of Science, Food, Agriculture 87: 1427–1434.
Lemay DG, Zivkovic AM and German JB (2007) Building the bridges to bioinformatics in nutrition research, American Journal of Clinical Nutrition 86: 1261–1269.
Leser ME, Sagalowicz L, Michel M and Watzke HJ (2006) Self-assembly of polar food lipids. Advances in Colloid Interface Science 123–126: 125-136.
Lock K, Pomerleau J, Causer L, Altmann DR and McKee M (2005) The global burden of disease attributable to low consumption of fruit and vegetables: Implications for the global strategy on diet. Bulletin of the World Health Organization.
Lopez AD, Mathers CD, Ezzati M, Jamison DT and Murray CJL (eds) (2006) Global Burden of Disease and Risk Factors. Oxford University Press: London.
Martinez JA, Corbalan MS, Sanchez‑Villegas A, Forga L, Marti A and Martinez‑Gonzalez MA (2003) Obesity risk is associated with carbohydrate intake in women carrying the Gln27Glu beta2‑adrenoceptor polymorphism. Journal of Nutrition 133: 2549–2554.
Matvienko O (2007) Impact of a nutrition education curriculum on snack choices of children ages six and seven years. Journal of Nutrition, Education and Behaviour 39: 281–285.
McCarthy FM, Wang N, Magee GB, Nanduri B, Lawrence ML, Camon EB, Barrell DG, Hill DP, Dolan ME, Williams WP, Luthe DS, Bridges SM and Burgess SC (2006) AgBase: A functional genomics resource for agriculture, BMC Genomics 7: 229.
Mero N, Suurinkeroinen L, Syvanne M, Knudsen P, Yki‑Jarvinen H and Taskinen MR (1999) Delayed clearance of postprandial large TG‑rich particles in normolipidemic carriers of LPL Asn291Ser gene variant. Journal of Lipid Research 40: 1663–1670.
Miller W, Makova KD, Nekrutenko A and Hardison RC (2004) Comparative genomics. Annual Review of Genomics and Human Genetics 5:15–56.
Morris RM (2006) Environmental genomics: exploring ecological sequence space. Current Biology 6: R499–501.
Moskowitz HR, German JB and Saguy IS (2005) Unveiling health attitudes and creating good-for-you foods: the genomics metaphor, consumer innovative web-based technologies. Critical Reviews of Foods Science and Nutrition 45: 165–191.
Nicholson JK and ID Wilson (2003) Opinion: understanding 'global' systems biology: metabonomics and the continuum of metabolism, National Review of Drug Discovery 2: 668–676.
Niewinski MM (2008) Advances in celiac disease and gluten-free diet. Journal of the American Dietetic Association 108:661–672.
Ordovas JM (2003) Cardiovascular disease genetics: a long and winding road. Current Opinions in Lipidology 14: 47–54.
Ostos MA, Lopez‑Miranda J, Ordovas JM, Marin C, Blanco A, Castro P, Lopez‑Segura F, Jimenez‑Pereperez J and Perez‑Jimenez FJ (1998) Dietary fat clearance is modulated by genetic variation in apolipoprotein A‑IV gene locus. Journal of Lipid Research 39: 2493–2500.
Petrovici DA and Ritson C (2006) Factors influencing consumer dietary health preventative behaviours. BMC Public Health 6: 222.
Pharkya P, Burgard AP and Maranas CD (2004) OptStrain: a computational framework for redesign of microbial production systems. Genome Research 14: 2367–76.
Plosch T, Kosters A, Groen AK and Kuipers F (2005) The ABC of hepatic and intestinal cholesterol transport. Handbook of Experimental Pharmacology 170: 465–482.
Popkin BM (2006) Global nutrition dynamics: The world is shifting rapidly toward a diet linked with noncommunicable diseases. American Journal of Clinical Nutrition 84: 289–298.
Quam L, Smith R and Yach D (2006) Rising to the global challenge of the chronic disease epidemic. Lancet 368: 1221–1223.
Raamsdonk LM, Teusink B, Broadhurst D, Zhang N, Hayes A, Walsh MC, Berden JA, Brindle KM, Kell DB, Rowland JJ, Westerhoff HV, van Dam K and Oliver SG (2001) A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations. Nature Biotechnology 19: 45–50.
Rantala M, Rantala TT, Savolainen MJ, Friedlander Y and Kesaniemi YA (2000) Apolipoprotein B gene polymorphisms and serum lipids: meta‑analysis of the role of genetic variation in responsiveness to diet, American Journal of Clinical Nutrition 71: 713–724.
Rezzi S, Ramadan Z, Martin FP, Fay LB, van Bladeren P, Lindon JC, Nicholson JK and Kochhar S (2007) Human metabolic phenotypes link directly to specific dietary preferences in healthy individuals. Journal of Proteome Research 6: 4469–4477.
Sagalowicz L, Leser ME, Watzke HJ and Michel M (2006) Monoglyceride self-assembly structures as delivery vehicles. Trends in Food Science Technology 17: 204–214.
Sajda P (2006) Machine learning for detection and diagnosis of disease, Annual Review of Biomedical Engineering 8: 537–565.
Sakly W, Thomas V, Quash G and El Alaoui S (2006) A role for tissue transglutaminase in α-gliadin peptide cytotoxicity. Clinical & Experimental Immunology 146: 550–558.
Schmitz G and Langmann T (2006) Pharmacogenomics of cholesterol-lowering therapy. Vascular Pharmacology 44: 75–89.
Schoenhagen P and Nissen SE (2006) Identification of the metabolic syndrome and imaging of subclinical coronary artery disease: early markers of cardiovascular risk. Journal of Cardiovascular Nursing 21: 291–297.
Schulze MB, Hoffmann K, Manson JE, Willett WC, Meigs JB, Weikert C, Heidemann C, Colditz GA and Hu FB (2005) Dietary pattern, inflammation, and incidence of type 2 diabetes in women. American Journal of Clinical Nutrition 82: 675–684.
Sebastian RS, Cleveland LE and Goldman JD (2008) Effect of snacking frequency on adolescents' dietary intakes and meeting national recommendations. Journal of Adolescent Health 42: 503–511.
Sloane EA (2006) Top ten functional food trends. Food Technology 60: 33.
Smotkin-Tangorra M, Purushothaman R, Gupta A, Nejati G, Anhalt H and Ten S (2007) Prevalence of vitamin D insufficiency in obese children and adolescents. Journal of Pediatric Endocrinology and Metabolism 20: 817–823.
Tedeschi LO, Fox DG, Chase LE and Wang SJ (2000) Whole-herd optimization with the Cornell Net Carbohydrate and Protein System. I. Predicting feed biological values for diet optimization with linear programming. Journal of Dairy Science 83: 2139–2148.
Tolstoguzov V (1986) Functional properties of protein-polysaccharide mixtures, in Functional Properties of Food Marcomolecules, JR Mitchell and DA Ledward (eds). Elsevier Applied Science, London, UK, pp.385–415.
Wang MY, Grayburn P, Chen S, Ravazzola M, Orci L and Unger RH (2008) Adipogenic capacity and the susceptibility to type 2 diabetes and metabolic syndrome. Proceedings of the National Academy of Sciences (USA) Apr 14.
Ward RE, Watzke HJ, Jiménez‑Flores R and German JB (2004) Bioguided processing: A paradigm change in food production. Food Technology 58: 44–48.
Whetstine JR, Witt TL and Matherly LH (2002) The human reduced folate carrier gene is regulated by the AP2 and sp1 transcription factor families and a functional 61‑base pair polymorphis. Journal of Biological Chemistry 277: 43873–43880.
Windhab EJ and Wildmoser H (2002) Extrusion: A novel technology for the manufacture of ice cream. Bulletin of the IDF 374: 43–49.
Womack JE (2005) Advances in livestock genomics: opening the barn door. Genome Research 15: 1699–705.
Xu J, Mahowald MA, Ley RE, Lozupone CA, Hamady M, Martens EC, Henrissat B, Coutinho PM, Minx P, Latreille P, Cordum H, Van Brunt A, Kim K, Fulton RS, Fulton LA, Clifton SW, Wilson RK, Knight RD and Gordon JI (2007) Evolution of symbiotic bacteria in the distal human intestine. PLoS Biology 5: e156.
Zeisel SH, Freake HC, Bauman DE, Bier DM, Burrin DG, German JB, Klein S, Marquis GS, Milner JA, Pelto GH and Rasmussen KM (2005) The nutritional phenotype in the age of metabolomics. Journal of Nutrition 135: 1613–1616.

eContent Home